COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS
摘要
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is -CR4=CR5.
申请公布号
HUE027249(T2)
申请公布日期
2016.10.28
申请号
HUE09718298
申请日期
2009.02.27
申请人
Novartis AG
发明人
WU, Tom Yao-Hsiang;LI, Yongkai;CORTEZ, Alex;ZOU, Yefen;MISHRA, Pranab;ZHANG, Xiaoyue;SKIBINSKI, David;SINGH, Manmohan;VALIANTE, Nicholas