Radiolabelled antibody and uses thereof

摘要

The present disclosure describes a radioconjugate of an anti-CD38 antibody and a radionuclide, e.g., Bi213.

主权项

1. A radioconjugate comprising an antibody specific for CD38 comprising an HCDR1 region of sequence GFTFSSYYMN (SEQ ID NO: 1) or SYYMN (SEQ ID NO: 14), an HCDR2 region of sequence GIS[ ]GDP[ ]SNTYY[ ]AD[ ]S[ ]VKG (SEQ ID NO: 2), an HCDR3 of sequence DLPLVYTGFAY (SEQ ID NO: 3), an LCDR1 region of sequence SGDNLRHYYVY (SEQ ID NO: 4), an LCDR2 region of sequence GDSKRPS (SEQ ID NO: 5), and an LCDR3 region of sequence QTYTGGASL (SEQ ID NO: 6).