Methods of specifically releasing a sub-group of objects

摘要

The present invention relates to a method of specifically releasing a one or more members of a sub-group of objects from an entity, a method of detecting a subject's disease by detecting one or more members of a sub-group of biological entities indicative of the disease and a method of isolating one or more members of a sub-group of objects from a group of objects.

主权项

1. A method of specifically releasing one or more members of a sub-group of objects from an entity, the method comprising
a) providing a heterogeneous group of objects comprising a homogeneous subgroup of objects, each member of the group of objects being bound to the entity via a linker; b) contacting the group of objects with an identifier, being capable of specifically binding the subgroup of objects, under conditions allowing the binding of the identifier to the subgroup of objects, wherein the identifier is coupled to a releaser being capable of releasing a member of the subgroup from the entity by interacting with the linker; c) binding the identifier to the subgroup, thereby bringing the releaser in proximity to the linker; and d) specifically releasing one or more members of the subgroup from the entity by allowing interaction between releaser and linker; thereby specifically releasing the one or more members of the subgroup of objects from the entity.