PROCESS FOR PRODUCING HETEROCYCLIC UREA DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Urea derivs. of formula (I), their hydrates and their pharmaceutically acceptable acid addn. salts are new, where R1 is piperidino or pyrrolidino, both opt. substd. by OH or 1-3C alkyl, A is ethylene, propylene orbut(en)ylene, R2 is 1-20C alkyl, 3-6C cycloalkyl, benzyl or phenyl opt. substd. by 1-3 of halo, 1-3C alkyl, 1-3C alkoxy, CF3, NH2, NO2 or OCH2O, and X is O or S. - Pref. R1 is piperidino or 4-hydroxy- or 4-methyl-piperidino, R2 is 1-6C alkyl or 3-6C cycloalkyl and A is propylene or butenylene. - N-(4-methoxyphenyl) -N'-(3-(3-piperidinomethyl phenoxy)propyl) urea is an example.