| 发明名称 |
Novel hydroxide mediated FK-506 rearrangement product. |
| 摘要 |
<p>A process is described involving an alkaline rearrangement of FK-506 producing a new decarbonylated 22-membered macrocycle rearrangement derivative of FK-506, i.e. C.9, nor-keto FK-506 (I). <CHEM> wherein R1 and R2 are independently H, or an easily removable hydroxy protecting group.</p> |
| 申请公布号 |
EP0364032(A2) |
申请公布日期 |
1990.04.18 |
| 申请号 |
EP19890202512 |
申请日期 |
1989.10.05 |
| 申请人 |
MERCK & CO. INC. |
发明人 |
ASKIN, DAVID;REAMER, ROBERT A.;JONES, TODD K.;VOLANTE, RALPH P.;SHINKAI, ICHIRO |
| 分类号 |
C07D498/18;A61K31/445;A61P37/06;C07F7/18;C07H19/01 |
主分类号 |
C07D498/18 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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