Apparatus, method and computer readable code for forecasting the onset of potentially life-threatening disease

摘要

Methods, systems and computer-readable code for generating a forecast of a life-threatening condition, for example sepsis, in a subject, for example an infant, are disclosed. According to some embodiments, the forecast is generated in accordance with measurement values for a plurality of different vital sign parameters. In exemplary embodiments, vital sign parameters from a plurality of physiological systems are used to generate the forecast of the life-threatening condition. In exemplary embodiments, at least one vital sign parameter is other than a cardiac parameter. Non-limiting exemplary vital sign parameters may include one or more of a heart rate parameter, a respiration rate parameter, a bradycardia parameter, a desaturation parameter, a temperature parameter (for example, body temperature) and a body mass parameter.

主权项

1. A method of advancing detection of a condition of sepsis in a premature infant by at least 18 hours, comprising:
a) using physiological sensors to acquire a plurality of different vital sign parameters of an infant, and providing measurement values to one or more processors of the plurality of different vital sign parameters of the infant, the plurality of different vital signs including a temperature parameter, a heart rate parameter, a respiration parameter, a desaturation parameter, a bradycardia parameter and a body weight parameter, the physiological sensors for the temperature parameter, the heart rate parameter, the respiration parameter, the desaturation parameter and the bradycardia parameter connected to the one or more processors; b) the one or more processors normalizing measurement values of the plurality of different vital signs including, for at least some of the different vital sign parameters of the infant, against historical values for said infant, the one or more processors transforming said normalized value; c) the one or more processors combining the transformed measurement values of the plurality of different vital sign parameters and thereby generating a single sepsis parameter, the single sepsis parameter comprising a single variable having a variable numerical value; d) the one or more processors monitoring the single sepsis parameter of the infant over time; and e) the one or more processors detecting a deviation from a normal range indicating the condition of sepsis in the infant from said single sepsis parameter when the single sepsis parameter moves beyond the normal range, said detecting the deviation advancing detection of the condition of sepsis in the infant by at least 18 hours.