发明名称 |
AMIDES OF CYCLOMETHYLEN-1,2-BICARBOXYLIC ACIDS HAVING THERAPEUTICAL ACTIVITY, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
摘要 |
<p>The amides of cyclomethylen-1,2-bicarboxylic acids having the formula: <CHEM> m is 0 or 1 and n is an integer varying between 0 and 3, are endowed with ACE-inhibiting activity and are thus therapeutically useful as anti-hypertension agents. For their preparation cyclomethylene-1,2-bicarboxylic acid or a derivative thereof is condensed either with an amino derivative containing a protected hydroxamic group, or with an aminoester, and then in the former case the protecting group is removed, or in the latter case is reacted with either hydroxylamine or N-alkylhydroxylamine.</p> |
申请公布号 |
EP0337348(A3) |
申请公布日期 |
1990.05.30 |
申请号 |
EP19890106304 |
申请日期 |
1989.04.10 |
申请人 |
LABORATORI GUIDOTTI S.P.A. |
发明人 |
TURBANTI, LUIGI;CERBAI, GUIDO;CRISCUOLI, MARCO |
分类号 |
A61K31/165;A61K31/16;A61P9/12;A61P43/00;C07C259/06;C07C259/08;(IPC1-7):C07C83/10 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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