PROCESS FOR PREPARING 2-OXA OR AZA-PREGMANE COMPOUNDS

摘要

Pregnane cpds. of formula (I) are obtd. from cpd. (II) by oxidn., then either redn., reacting with HX, dehydration, oxidn., reacting R1Y and reducing/RNH2, RNH2/HCO2H or reducing or sequence of corresp. reactions. In the formulas, A=H or C2-6 lower alkanoyl, pref. acetyl; Z= O or -BR- (R= H or C1-6 alkyl); X= halo (pref. Cl).; R1= lower alkyl; Y= I or Br. (I) have anti-androgenic activity and useful for controlling androgen-dependent diseases, esp. for preventing hypertrophy.