发明名称 |
PROCESS FOR PRODUCING OPTICALLY ACTIVE OXOISOINDOLINYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS |
摘要 |
Optically active oxo-isoindolinyl compounds of formula (I> <IMAGE> wherein R is C1-C4 alkyl; and R1 is hydrogen, C1-C4 alkyl or <IMAGE> wherein n is 1 or 2 and each of R2 and R3, which may be the same or different, is hydrogen or C1-C4 alkyl, or physiologically acceptable salts thereof, are prepared by resolving a racemic compound of formula (II): <IMAGE> into its optical isomers, to give an optically active compound of formula (II) as such or as a salt; reacting the said compound or salt with o-phthalic anhydride to give the corresponding optically active phthalimido compound; and reducing the optically active phthalimido compound. The product obtained can be esterified or salified as desired. The resultant optically active compounds, in particular that in which R is ethyl, exhibit platelet aggregation inhibiting activity. |
申请公布号 |
HU201011(B) |
申请公布日期 |
1990.09.28 |
申请号 |
HU19880001124 |
申请日期 |
1988.03.08 |
申请人 |
FARMITALIA CARLO ERBA S.P.A.,IT |
发明人 |
CARNEL,GIOVANNI,IT;ORZI,FABRIZIO,IT;CERONI,GIORGIO,IT;MIORINI,BRUNO,IT;GRIGGI,PIERLUIGI,IT |
分类号 |
C07D209/46;A61K31/40;A61K31/403;A61K31/4035;A61P7/02;A61P9/00;A61P25/04;A61P29/00;C07B53/00;(IPC1-7):C07D209/46 |
主分类号 |
C07D209/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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