发明名称 |
PROCESS FOR THE PREPARATION OF THE L-ARGININE SALT OF PERINDOPRIL |
摘要 |
Preparing perindopril L-arginine salt (I) comprises reacting perindopril and L-arginine in a solvent system comprising a binary mixture of acetonitrile and dimethyl sulfoxide, a binary mixture of ethyl acetate and dimethyl sulfoxide, and a ternary mixture of acetonitrile, dimethyl sulfoxide and toluene, at a temperature of 10-100[deg] C; and isolating (I) by filtration. ACTIVITY : Cardiovascular-Gen.; Hypotensive; Cardiant; Vasotropic. MECHANISM OF ACTION : Angiotensin I converting enzyme inhibitor. |
申请公布号 |
HRP20161145(T1) |
申请公布日期 |
2016.11.18 |
申请号 |
HR2016P001145T |
申请日期 |
2016.09.06 |
申请人 |
Les Laboratoires Servier |
发明人 |
Linol, Julie;Laurent, Stéphane;Grenier, Arnaud;Mathieu, Sébastien |
分类号 |
C07D209/42 |
主分类号 |
C07D209/42 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|