| 发明名称 |
METHOD FOR PRODUCING RECOMBINANT IMMUNOGLOBULINS |
| 摘要 |
JLT 4Y 18063Y TITLE OF THE INVENTION METHOD FOR PRODUCING RECOMBINANT IMMUNOGLOBULINS A method for producing recombinant immunoglobulins in which the unique complementarity determining regions of immunoglobulins from a first animal monoclonal antibody are inserted by recombinant technology into a uniquely selected framework of a second animal, including humans. The recombinant DNA constructs of the invention can be used to transfect cells which will produce the recombinant immunoglobulins.
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| 申请公布号 |
CA2034553(A1) |
申请公布日期 |
1991.07.20 |
| 申请号 |
CA19912034553 |
申请日期 |
1991.01.18 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
LAW, MING-FAN;MARK, GEORGE E., III;SINGER, IRWIN I.;WILLIAMSON, ALAN R. |
| 分类号 |
C12N15/09;C07K16/46;C12N15/13;C12P21/02;C12P21/08;C12Q1/68;C12R1/91;(IPC1-7):C12P21/00 |
主分类号 |
C12N15/09 |
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