PROCESS FOR PREPARING N-PHENYL-N-METHOXYACETYL-DL-ALANINE METHYLESTER

摘要

PROCESS FOR PREPARING N-PHENYL-N-METHOXYACETYL- -DL-ALANINE-METHYLESTER DERIVATIVES The invention relates to a new process for the preparation of N-phenyl-N-methoxy- -acetyl-DL-alanine methylester of the general formula (I) wherein R stands for hydrogen atom or C1-C4 alkyl group The process discloses the acylation of a substituted aniline of the general formula (II) with a mixture of methoxyacetic acid and phosphorous trichloride in a solvent then alkylation of the obtained N-methoxyacetyl-aniline derivative of the general formula (Ill) with an alkyl halogenide in the presence of an alkali metal, alkali metal alcoholate, alkali metal amide or complex metalhydride..