BENZOTHIAZEPINE ESTERS, THEIR PREPARATION AND FORMULATIONS FOR THERAPEUTIC USE

摘要

NOVEL BENZOTHIAZEPINE ESTERS, THEIR PREPARATION AND FORMULATIONS FOR THERAPEUTIC USE A class of benzothiazepine esters having structures related -to that of diltiazem are provided which possess vasodilating activity while being virtually free of cardiodepressive effects. The esters are useful in the treatment of arterial hypertension and disturbances of the cerebral circulation. The compounds have the general formula I herein R represents hydrogen or an electronegative group (preferably a halogen atom~ or a nitro, trifluoromethyl or methoxy group); and X is a hydrocarbyl group containing from 1 to 15 carbon atoms.