INHIBITION OF MAMMALIAN MUSCLE WASTING AND PROTEIN DEGRADATION BY TETRACYCLINES
摘要
A method for treating mammals suffering from skeletal muscle wasting and/or intracellular protein degradation of skeletal muscle systems by administering to the mammal an amount of tetracycline which results in a significant reduction of the muscle wasting and protein degradation is disclosed. In addition, there is also disclosed a method of increasing the protein content of skeletal muscle systems of mammals by administration of tetracyclines. The tetracyclines useful in the above methods are both antimicrobial and non-antimicrobial. In a preferred embodiment, the method of treatment utilizes a non-antimicrobial tetracycline such as dedimethylaminotetracycline (CMT).
申请公布号
CA2045885(A1)
申请公布日期
1991.12.29
申请号
CA19912045885
申请日期
1991.06.27
申请人
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (THE)
发明人
SCHNEIDER, BRUCE;GREENWALD, ROBERT A.;MAIMON, JONATHON;GORRAY, KENNETH;GOLUB, LORNE M.;MCNAMARA, THOMAS F.;RAMAMURTHY, NANGAVARUM S.