Elfamycin-resistant mutants.

摘要

Elfamycin-producing actinomycetes, in particular the mocimycin-producing streptomycetes, are frequently too sensitive for the elfamycin produced by them. This limiting factor for the production of the elfamycin concerned is removed by mutating the gene tuf, encoding the protein EF-Tu, into a gene tufR, encoding a protein EF-TuR, which protein is resistant to the elfamycin concerned. The gene tufR is expressed in host cells which than show an increased resistance to the elfamycins tested.