NEW BENZENE DERIVATIVES HAVING NGF PRODUCTION-PROMOTING ACTIVITY

摘要

Novel benzene derivatives are provided of the general formula (I): (I) ¢wherein R1 represents an amino group, a substituted amino group, a protected amino group, or a nitro group; R2 represents an amino group, a substituted amino group, a protected amino group, a hydroxy group, a substituted hydroxy group, or a protected hydroxy group; R3 represents an amino group, a substituted amino, a heterocyclyl group having a ring nitrogen atom as the point of binding, or a substituted heterocyclyl group having a ring nitrogen atom as the point of binding; m is 0 to 2; a is 0 to 6; with the proviso that when m is 0, then n represents an integer from 2 to 6! and salts thereof. Compounds of formula (I) except those wherein R1 is a nitro group have activity in promoting production of nerve growth factor. Compounds of formula (I) wherein R1 is a nitro group are intermediates for compounds of formula (I) wherein R is an amino group.