IMPROVED RETARD SYSTEMS FOR THE SUSTAINED RELEASE OF MEDICINAL AND/OR BIOLOGICAL VALUABLE MATERIALS FROM A DEPOT CARRIER MATERIAL

摘要

IMPROVED RETARD SYSTEMS FOR THE SUSTAINED RELEASE OF MEDICINAL AND/OR BIOLOGICAL VALUABLE MATERIALS FROM A DEPOT CARRIER MATERIAL The invention, in a first embodiment, relates to the use of free radical-reactive cross-linker components based on olefinically unsaturated esters of lower hydroxycarboxylic acids and/or oligomers thereof for modifying depot materials, and especially retard systems, which contain medicinal and/or biological valuable materials in admixture with a carrier material in a sustained release of the active substance(s) in practical application. The cross-linkers are present as polymer compounds in the application form of the retard system and may be provided in the retard system or depot material to be applied in a largely homogeneous as well as in a non-uniform distribution. The invention further relates to retard systems which contain medicinal and/or biological valuable materials and have been based on oligomer and/or polymer compounds of lower hydroxycarboxylic acids as carrier materials providing a sustained release of the active substance, the invention being characterized in that said retard systems and/or depot materials have been modified with polymer compounds prepared from olefinically unsaturated esters of lower hydroxycarboxylic acids and/or oligomers thereof.