发明名称 |
SOLUBLE SALTS OF IBUPROFEN AND NAPROXEN WITH N-(2-HYDROXYETHYL) PYRROLIDINE AND PHARMACEUTIC COMPOSITIONS CONTAINING SAID SALTS |
摘要 |
The salts, in the crystalline form, of ibuprofen and naproxen with N-(2-hydroxyethyl) pyrrolidine are prepared by dissolving ibuprofen and naproxen respectively in a suitable organic solvent, by adding N-(2-hydroxyethyl) pyrrolidine, by letting the compounds react, by removing the solvent and by crystallizing the obtained salt from a solution in an apolar and aprotic solvent. Said salts have a high solubility in water and are used for preparing pharmaceutic compositions for oral and other administrations.
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申请公布号 |
CA2072407(A1) |
申请公布日期 |
1993.01.02 |
申请号 |
CA19922072407 |
申请日期 |
1992.06.25 |
申请人 |
ALTERGON S.A. |
发明人 |
DONATI, ELISABETTA;RAPAPORT, IRINA;LUALDI, PAOLO |
分类号 |
A61K31/205;C07C57/30;C07C59/64;C07D295/088;(IPC1-7):C07D295/088;A61K31/19;A61K31/40 |
主分类号 |
A61K31/205 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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