3-DEOXY-MANNOSAMINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION

摘要

The present invention relates to 3-deoxy-derivatives of D-mannosamine of formula (I) wherein R is -NH2 or a C2-C5 alkanoyl-NH- or CF3CONH- group; each of R1 and R2 independently is C1-C4 alkyl, or R1 is hydrogen, halogen, C1-C4 alkyl or C1-C4 alkoxy, and R2 is hydrogen or both of R1 and R2 are fluorine; and wherein, when R1 is methoxy and R2 is hydrogen then R is other than -NH2, or a pharmaceutically acceptable salt thereof, which are useful as angiogenesis inhibitors, in particular as development of metastasis inhibitors.