发明名称 |
USE OF BINDING PROTEIN WITH IGF-I AS AN ANABOLIC GROWTH PROMOTING AGENT |
摘要 |
A method is disclosed for producing an anabolic state in a mammal by co-administration by subcutaneous injection of a combination of effective amounts of IGF-I and an IGF binding protein in a defined molar ratio in the absence of growth hormone so as to produce a greater anabolic response in the mammal than that achieved using IGF-I alone in an amount equal to that used for IGF-I in the combination. Preferably, the IGF-I is native-sequence, mature human IGF-I, the binding protein is IGFBP-3, and the mammal is human or a non-human animal of economic importance such as a cow or pig.
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申请公布号 |
US5187151(A) |
申请公布日期 |
1993.02.16 |
申请号 |
US19910654436 |
申请日期 |
1991.02.12 |
申请人 |
GENENTECH, INC. |
发明人 |
CLARK, ROSS G.;MUKKU, VENKAT R. |
分类号 |
A61K38/00;A61K38/27;A61K38/30;C07K14/47 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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