发明名称 |
DNA encoding hybrid streptokinases with plasminogen fibrin binding domains |
摘要 |
Compositions and methods of the synthesis of hybrid streptokinase with fibrin binding domains based on gene fusion technology. Recombinant DNA methods have been used to fuse gene segments for streptokinase and for fibrin-binding domains and express the fused gene in prokaryotic microorganisms, and the respective expressed protein is subsequently obtained by biotechnologic fermentation for the purpose of use in clinical medicine.
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申请公布号 |
US5187098(A) |
申请公布日期 |
1993.02.16 |
申请号 |
US19920888420 |
申请日期 |
1992.05.22 |
申请人 |
BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA |
发明人 |
MALKE, HORST;FERRETTI, JOSEPH J. |
分类号 |
C07K14/315;C12N1/21;C12N9/68;C12N9/72 |
主分类号 |
C07K14/315 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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