摘要 |
<p>The invention relates to acetic acid derivatives of formula (I) and pharmaceutically acceptable derivatives thereof and salts and solvates thereof, in which X?1 and Y1¿, which may be the same or different, represent CH or N; X2 represents CH or, when X1 represents CH, may also represent N; Y2 represents N or, when Y1 represents N, may also represent CH; Z represents N or N+R5; R1 represents a hydrogen atom or a hydroxyl, C¿1-4?alkyl or 2,2,2-trifluoroethyl group; R?2¿ represents a hydrogen atom or, when both X?1 and X2¿ represent CH, may also represent a fluorine, chlorine or bromine atom or a C¿1-4?alkyl group; R?3¿ represents a hydrogen atom or, when both Y?1 and Y2¿ represent N, may also represent a C¿1-4?alkyl or hydroxymethyl group. R?4¿ represents a hydrogen atom or, when Z represents N, R4 may also represent a C¿1-4?alkyl group; R?5¿ represents a C¿1-4?alkyl or phenylC1-4alkyl group; R?6¿ represents a hydrogen atom or a C¿1-4?alkyl group. The compounds inhibit fibrinogen-dependent blood platelet aggregation.</p> |