| 摘要 |
<p>A benzodiazepine derivative of formula (I), or a pharmaceutically acceptable salt thereof, wherein (a) R1 is -CH¿2?CHOH(CH2)aR?4¿ or a ketone group -CH¿2?CO(CH2)aR?5¿ in which a is 0 or 1 and R?4 and R5¿ are selected from alkyl and cycloalkyl groups and saturated heterocyclic groups optionally substituted at a hetero-atom; (b) R?2 and R3¿ are independently selected from aromatic carbocyclic and heterocylic residues; and (c) W and X are selected independently from halogen and hydrogen atoms and alkyl and alkoxy groups. These compounds are gastrin and/or CCK-B receptor antagonists.</p> |
