| 摘要 |
The invention relates to compounds of formula (I). <CHEM> or a salt, or metabolically labile ester thereof wherein R represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SO2R1 or COR1 wherein R1 represents hydroxy, methoxy, or amino; m is zero or an integer 1 or 2; A represents an ethynyl group or an optionally substituted ethenyl, or cyclopropyl group; X represents -O- or NH; R2 represents an aryl group and when X represents an oxygen atom R2 may also represent a hydrogen atom or an alkyl group; which are antagonists of excitatory amino acids, to processes for their preparation and to their use in medicine. |
