| 摘要 |
<p>A (4R)-3-(substituted aminoalkyl)oxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(nitrophenyl)pyridine-5-carboxylic acid can be produced efficiently by the reaction of a bis(substituted aminoalkyl) 1,4-dihydro-2,6-dimethyl-4-(nitrophenyl)pyridine-3,5-dicarboxylate with a microorganism, or a product of treatment thereof, which can induce asymmetric hydrolysis and belongs to the genus Streptomyces, Paecilomyces, Botryodioplodia, Alternaria or Helminthosporium. This compound is extremely useful as an important intermediate for producing medicines useful for preventing or treating angina pectoris, hypertension and so forth.</p> |
