发明名称 |
MODIFIED PLATELET FACTOR-4 |
摘要 |
The present invention is based of the discovery of two modified forms of human platelet factor-4, herein named MPF-4 and CPF-4, which were isolated from serum free culture medium of lipopolysaccharide-stimulated peripheral blood leukocytes. Amino acid sequence determination revealed that MPF-4 shares homology with platelet factor-4 beginning at N-terminal residue 17. CPF-4 consists of MPF4 disulfide bonded to the 16 N-terminal residues of platelet factor-4. Both MPF-4 and CPF-4 are potent inhibitors of endothelial cell proliferation, approximately 10-100 fold more potent than native or recombinant platelet factor-4, making them useful in the treatment of angiogenic diseases.
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申请公布号 |
CA2106629(A1) |
申请公布日期 |
1994.03.26 |
申请号 |
CA19932106629 |
申请日期 |
1993.09.21 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
GUPTA, SHALLEY K.;SINGH, JAI P. |
分类号 |
A61K38/00;A61P35/00;A61P43/00;C07K7/14;C07K14/52;C12N15/19;C12P21/02;C12R1/91;(IPC1-7):C12N15/12;C07K1/14;A61K38/36;C07K14/745 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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地址 |
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