Benzenesulphonamide derivatives

摘要

The invention concerns benzenesulphonamide derivatives of the formula I <IMAGE> I wherein R1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; R2 and R3 together form -A2-X2-A3- which defines a ring having 5 or 6 ring atoms, wherein A2 and A3 each is (1-3C)alkylene and X2 is oxy, thio, sulphinyl or sulphonyl; A1 is a direct link to X1 or is (1-3C)alkylene; X1 is oxy, thio or imino; Ar is optionally substituted phenylene; R4 is (1-4C)alkyl, fluoro-(2-4C)alkyl or optionally substituted phenyl or a heterocyclic moiety; R5 is hydrogen or (1-4C)alkyl; and R6 is hydrogen, halogeno, trifluoromethyl, (1-4C)alkyl or (1-4C)alkoxy; or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.