发明名称 |
PROCESS FOR THE ENZYMATIC PREPARATION OF OPTICALLY ACTIVE TRANSGLYCIDIC ACID ESTERS |
摘要 |
The invention relates to the preparation of an optically active ester of trans-3-phenylglycidic acid in which a mixture of the 2 enantiomers of the trans-3-phenylglycidic acid ester is stereoselectively hydrolyzed using an enzyme originating from Candida antarctica and the non-hydrolyzed ester is separated off from the reaction mixture. A racemic mixture of trans-phenylglycidic acid esters is selectively and enzymatically hydrolyzed in a relatively short reaction time, the residual ester being obtained in a high yield and with a high e.e. Such esters are used for the preparation of pharmaceuticals such as benzothiazepines and benzazepines.
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申请公布号 |
CA2111595(A1) |
申请公布日期 |
1994.06.19 |
申请号 |
CA19932111595 |
申请日期 |
1993.12.16 |
申请人 |
DSM N.V. |
发明人 |
KIERKELS, JOANNES G. T.;PEETERS, WIJNAND P. H. |
分类号 |
C07D303/48;C12P17/02;C12P41/00;(IPC1-7):C12P41/00;C07D281/02;C07D223/16 |
主分类号 |
C07D303/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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