发明名称 |
TRI-SPECIFIC BINDING MOLECULES THAT SPECIFICALLY BIND TO MULTIPLE CANCER ANTIGENS AND METHODS OF USE THEREOF |
摘要 |
The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Tri-Specific Binding Molecule is preferably characterized in possessing binding domains that permit it to immunospecifically bind to: (1) an epitope of a first Cancer Antigen, (2) an epitope of a second Cancer Antigen, and (3) an epitope of a molecule that is expressed on the surface of an immune system effector cell, and are thus capable of localizing an immune system effector cell to a cell that expresses a Cancer Antigen, so as to thereby facilitate the killing of such cancer cell. |
申请公布号 |
SG11201609912T(A) |
申请公布日期 |
2016.12.29 |
申请号 |
SGT11201609912 |
申请日期 |
2015.05.29 |
申请人 |
MACROGENICS, INC. |
发明人 |
BONVINI, EZIO;MOORE, PAUL, A.;LI, JONATHAN, C.;JOHNSON, LESLIE, S.;SHAH, KALPANA |
分类号 |
A61K39/395;C07K16/00;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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