发明名称 |
NOVEL CHOLECYSTOKININ ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC USE |
摘要 |
Novel cholecystokinin antagonists useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with use of nicotine, diazepam, alcohol, cocaine, coffee, or opioids. The compounds of the invention are also useful in treating and/or preventing panic. Also disclosed are pharmaceutical compositions and methods of treatment using the antagonists as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions. |
申请公布号 |
EP0547178(A4) |
申请公布日期 |
1994.07.06 |
申请号 |
EP19910918880 |
申请日期 |
1991.08.29 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
HORWELL, DAVID CHRISTOPHER;KLEINSCHROTH, JUERGEN;REES, DAVID, CHARLES;RICHARDSON, REGINALD STEWART;ROARK, WILLIAM, HOWARD;ROBERTS, EDWARD;ROTH, BRUCE, DAVID;TRIVEDI, BHARAT, KALIDAS;HOLMES, ANN;PADIA, JANAK, KHIMCHAND |
分类号 |
A61K31/335;A61K31/35;A61K31/351;A61K31/357;A61K31/40;A61K31/403;A61K31/404;A61K31/415;A61K31/425;A61K31/426;A61K31/66;A61K38/00;A61P1/04;A61P25/18;A61P25/30;A61P35/00;C07D209/14;C07D209/16;C07D209/18;C07D209/20;C07D233/20;C07D233/64;C07D249/08;C07D257/04;C07D277/12;C07D277/20;C07D277/32;C07D309/38;C07D317/18;C07D317/28;C07D317/30;C07D403/12;C07D405/12;C07D413/12;C07D417/12;C07K5/02;C07K5/06;C07K5/065;C07K5/078;C07K14/575;C07K14/595;C07K14/655 |
主分类号 |
A61K31/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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