Method of preparing optically active alcohols which consist substantially or entirely of one enantiomer

摘要

The invention relates to a method of preparing optically active alcohols which consist substantially (at least 75% e.e.) or entirely of one enantiomer of formula 4 <IMAGE> (4) wherein R and A are as defined therein. The method comprises, which maintaining enantiomeric excess, converting an optically active cyanohydrin of formula 1 <IMAGE> (1) into optically active protected cyanohydrin of formula 2 <IMAGE> (2) converting the protected cyanohydrin of formula 2 into an optically active compound of formula 3 <IMAGE> (3) removing the protecting group B.