| 摘要 |
PCT No. PCT/US94/07769 Sec. 371 Date Jan. 16, 1996 Sec. 102(e) Date Jan. 16, 1996 PCT Filed Jul. 11, 1994 PCT Pub. No. WO95/02587 PCT Pub. Date Jan. 26, 1995The invention is directed to a series of novel compounds of the formula <IMAGE> where Y is carbonyl or sulfonyl; R7 and R8 are alkyl, or R7 and R8, together with the carbon to which they are attached, form a C3-6 carbocyclic ring; R9 and R10 are each independently selected from hydrogen, hydroxyl, oximido, methyl, carboxyl, carboxyalkyl, unsubstituted or substituted alkoxycarbonyl, alkylcarbonyloxyalkyl, cyanoalkyl, hydroxyalkyl or unsubstituted amino; R11 is hydrogen, oxo, -N(R12)-CO-R13 or -CO-N(R14)-R15; R12 is hydrogen or unsubstituted or substituted alkyl; R13 is alkoxyl, unsubstituted or substituted heterocyclic rings selected from <IMAGE> <IMAGE> <IMAGE> <IMAGE> or unsubstituted or substituted alkyl; and R14 and R15 are each independently selected from hydrogen or unsubstituted or substituted alkyl. The Y moiety cannot be bonded to the camphor ring at the 3 or 6 positions. Such compounds are oxytocin antagonists useful in the treatment of preterm labor, dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery. |
