DNA FRAGMENT CARRYING THE GENE ENCODING THE ENZYME FOR FRAGMENTING N-ACETYLHEPAROSAN AND THE ADJACENT SEQUENCES PERMITTING ITS EXPRESSION, RECOMBINANT ENZYME INTENDED FOR FRAGMENTING N-ACETYLHEPAROSAN AND ITS USE

摘要

DNA fragment carrying the gene encoding the enzyme for fragmenting N-acetylheparosan and the adjacent sequences permitting its expression, recombinant enzyme intended for fragmenting N-acetylheparosan and its use SANOFI 32-34 Rue Marbeuf 75008 PARIS The invention relates to a DNA fragment of sequence S1 as described in the application and encoding the S2 peptide sequence as described in the application. This DNA sequence carries the gene encoding the enzyme for fragmenting N-acetylheparosan and the adjacent sequences permitting its expression. The invention also relates to an enzyme intended for fragmenting N-acetyl-heparosan derived from this gene and the processes for fragmenting high molecular mass N-acetylheparosan using this enzyme.