发明名称 |
SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE DERIVATIVES. |
摘要 |
<p>An improved process is described for obtaining triazacyclononanes, esepcially 1,4,7-trimethyl-1,4,7-triazacyclononame. The first step involves reacting diethylenetriamine (DET) with a sulfonylation agent to form a sulfonamidated DET, in an aqueous medium with an inorganic base. In a second step, but preferably within the same reactor vessel without isolating intermediates, the sulfonamidated DET aqueous mixture is contacted with an aprotic organic solvent in the presence of a cyclizing unit such as ethylene glycol ditosylate or ethylene dibromide, thereby resulting in a cyclized sulfonamidated triamine compound. Thereafter the protecting groups are removed and the amine is alkylated, preferably within a single reaction vessel without isolation of intermediates.</p> |
申请公布号 |
EP0648211(A1) |
申请公布日期 |
1995.04.19 |
申请号 |
EP19930914669 |
申请日期 |
1993.06.16 |
申请人 |
UNILEVER PLC;UNILEVER N.V. |
发明人 |
MADISON, STEPHEN, ALAN;BATAL, DAVID, JOHN |
分类号 |
C07D255/02;(IPC1-7):C07D255/02 |
主分类号 |
C07D255/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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