ANTI-VIRAL GUANIDINO-SUBSTITUTED COMPOUNDS

摘要

Novel guanidino-substituted compounds are described having general formula (I) or a salt, hydrate or solvate thereof, wherein X is selected from C, O, N and S; R1 is -(W)a-(R4)b-Z, wherein a and b are independently 0 or 1; W is NH, O or S; R4 is C1-8alkylene in which one or two of the carbon atoms thereof is optionally replaced with nitrogen or oxygen; and Z is H, OH or -NH-C(NH)-NH2; R2 and R3 are, independently, C1-8alkylene in which one of the carbon atoms thereof is optionally replaced with nitrogen or oxygen. These compounds have been found to inhibit effectively herpesvirus replication. Particularly preferred compounds in accordance with formula (I) for this purpose are guanidino-substituted sugar derivatives.