| 摘要 |
The present invention is directed to an effective process for preparing a carbapenem compound of the formula (III): <IMG> (III) wherein R1 and R2 are each H or lower alkyl, R3 is lower alkyl, R4 is a protecting group, L is substituted or unsubstituted arylsulfonyloxy, lower alkanesulfonyloxy, halogeno-lower alkanesulfonyloxy, di-lower alkylphosphoryloxy, etc., and X is H or protected hydroxy, which comprises reacting .beta.-lactam compound (I) with acetic acid ester derivative (II), in the presence of a base, followed by treating the product with an active esterifying agent for hydroxy group. The compounds of the formula (III) are useful as intermediates in the preparation of 1.beta.-alkylcarbapenem compounds having antibacterial activity.
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