| 摘要 |
The invention relates to a 11,21-bisphenyl-19-norpregnane derivative of formula I <CHEM> wherein R1 is selected from H, halogen, (1-6C)alkoxy, and NR5R6, R5 and R6 being independently hydrogen or (1-6C)alkyl or R5 and R6 together are (3-6C)alkylene; R2 is hydrogen; or R1 and R2 together are a (1-3C)alkylenedioxy group, optionally substituted by one or more halogen atoms; R3 is methyl or ethyl; R4 is selected from C(O)-NR5R6, SOn-(1-6C)alkyl optionally substituted by one or more halogen atoms, SOn-(3-6C)cycloalkyl, n being 1 or 2, SO2-NR5R6, 2-oxypyrrolidinyl, and NR5R6; R7 is H or (1-6C)alkyl; R8 is H or carboxy-1-oxo(1-6C)alkyl; and X is selected from (H,OH), O, and NOH; 11 or a pharmaceutically acceptable salt thereof. The compounds of the invention have anti-glucocorticoid activity and can be used in treating or preventing glucocorticoid-dependent diseases. |
