The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
In a preferred embodiment, co-crystals of (-)tramadol-(S)-naproxen (1:2) and (+)tramadol-(R)-naproxen (1:2) are prepared.
申请公布号
DK2349238(T3)
申请公布日期
2016.12.12
申请号
DK20090736862T
申请日期
2009.10.16
申请人
LABORATORIOS DEL DR. ESTEVE, S.A.
发明人
BENET BUCHHOLZ, Jordi;BUSCHMANN, Helmut, Heinrich;Bertran, Jordi Carles Ceron;Plata Salaman, Carlos Ramon;SOLÿ CARANDELL, Lluis;Tesson, Nicolas