Forbedrede retarderingssystemer til forsinket frigivelse af medicinsk og/eller biologisk værdifulde stoffer fra et depotbæremateriale

摘要

PCT No. PCT/EP92/00825 Sec. 371 Date Oct. 18, 1993 Sec. 102(e) Date Oct. 18, 1993 PCT Filed Apr. 11, 1992 PCT Pub. No. WO92/18108 PCT Pub. Date Oct. 29, 1992The invention relates to the use of free radical-reactive cross-linker components based on olefinically unsaturated esters of lower hydroxycarboxylic acids and/or oligomers thereof for modifying depot materials, and especially retard systems, which contain medicinal and/or biological valuable materials in admixture with a carrier material in a sustained release form. The cross-linkers are present as polymer compounds in the application form of the retard system and may be provided in the retard system or depot material to be applied in a largely homogeneous as well as in a non-uniform distribution. The invention also relates to retard systems which contain medicinal and/or biological valuable materials and have been based on oligomer and/or polymer compounds of lower hydroxycarboxylic acids as carrier materials providing a sustained release of the active substance. The retard systems and/or depot materials are modified with polymer compounds prepared from olefinically unsaturated esters of lower hydroxycarboxylic acids and/or oligomers thereof.