发明名称 |
T CELL RECEPTOR LIKE ANTIBODIES HAVING FINE SPECIFICITY. |
摘要 |
An antibody capable of binding, with a human major histocompatibility complex (MHC)-restricted specificity, a MHC being complexed with an HLA-restricted peptide antigen is provided. The antibody having a binding specificity dictated by at least 4 amino acid residues in said HLA-restricted peptide such that at least 70 % reduction in binding of said antibody to said complex is observed when each of said at least 4 amino acid residues is substituted as determined by FACS of cells loaded with said HLA-restricted peptide comprising said substitution, said at least 4 amino acid residues not being anchor residues. |
申请公布号 |
NL2014935(A) |
申请公布日期 |
2016.12.12 |
申请号 |
NL20152014935 |
申请日期 |
2015.06.08 |
申请人 |
APPLIED IMMUNE TECHNOLOGIES LTD. |
发明人 |
MIRA PELED KAMAR;GALIT DENKBERG;YORAM REITER;ILAN BEER;KEREN SINIK;YAEL TEBOUL (ELBAZ);YAEL SHPERBER (SERY);REUT EREL SEGAL |
分类号 |
C07K16/28;C07K16/30;C07K16/40 |
主分类号 |
C07K16/28 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|