4-phenyl-4-(N-(2-fluorophenyl)amido) piperidine derivatives

摘要

Compounds of the formula: and/or pharmaceutically acceptable acid addition salts thereof, in which formula: R<1> is phenyl; R<2> is phenyl unsubstituted or substituted with one or more halogens; R<3> is a lower alkyl, a lower cycloalkyl or a lower alkoxy lower alkyl group; and L is a lower alkenyl group or a substituted lower alkyl group which is thienyl lower alkyl; thiazolyl lower alkyl; [4-(lower alkyl) thiazolyl] lower alkyl; (4,5-dihydro-5-oxo-1H-tetrazol-y-1-yl) lower alkyl; [4-(lower alkyl) 4,5-dihydro-5-oxo-1H-tetrazol-1-yl] lower alkyl; 1H-pyrazolyl lower alkyl; 2-(2-dihydro-2-oxo-3H-benzoxazol-3-yl) lower alkyl; pyridyl lower alkyl; [(2-lower alkyl)5-nitro-1H-imidazol-1-yl] lower alkyl; [4-(halo) 1H-pyrazolyl] lower alkyl substituted in the 4 position by a halogen; lower cycloalkyl lower alkyl or phenyl lower alkyl have analgesic properties.