摘要 |
Procedure for obtaining coated particles of 1-cyclopropyl- 7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acid, in which the active principle is dispersed in a water-soluble polymeric agglutinating agent, followed by spraying, coacervation or granulation. The particles so obtained exhibit less direct contact between the active principle and the buccal mucosa, thus providing a form of administration without the disadvantages associated with the unpleasant taste of the active principle, which may cause rejection, while at the same time giving good gastric tolerance and good bioavailability. The product so obtained is useful as a broad-spectrum antibacterial agent. Identical methods can be used to obtain coated particles of the remaining broad-spectrum antibacterial agents belonging to the family of the quinolones or quinolinecarboxylic acid derivatives.
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