DERIVATIVES OF CYCLOHEXENE SUBSTITUTED BY FLUORINE

摘要

Fluorine substituted cyclohexene derivatives are prepared which is useful for intermediates in synthesizing terpene compounds or active components of agricultural agents and medicines, by reacting 4-trifluoromethyl-3-penten-2-one with ethyl acetoacetate. 4-trifluoromethyl-3-penten-2-one which is formed from acetylmethylene triphenylphosphorane and trifluoroacetone is reacted with ethyl acetoacetate in benzene in the presence of sodium ethoxide at 60 deg. C to produce 3,5-dimethyl-5-trifluoromethyl-2-cyclohexen-1-one, which is subsequently reacted with methyl magnesium iodide and ferric chloride to obtain 3,5-dimethyl-5-trifluoromethyl-3-cyclohexen-1-one.