发明名称 |
TRANSFECTION COMPETENT MOLECULES |
摘要 |
The invention relates to conjugates of lipids and basic, membrane disturbing peptides. particularly compounds of the formulae (R-CONH)n-R3 (I) and (R-S-S)n-R3 (II) wherein R is the hydrocarbyl moiety of a straight-chain or branched-chain, saturated or unsaturated aliphatic carboxylic acid, or a phospholipid moiety having a free valence bond; R3 is a basic membrane disturbing peptide having a free valence bond at one or two carbon atom(s); and n is 1 or 2. which can be used as a vector for transfecting a cell with a polynucleotide or any other anionic macromolecule. |
申请公布号 |
CA2195169(A1) |
申请公布日期 |
1997.07.18 |
申请号 |
CA19972195169 |
申请日期 |
1997.01.15 |
申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
LEGENDRE, JEAN-YVES;SUPERSAXO, ANDREAS;TRZECIAK, ARNOLD |
分类号 |
C12N15/09;A61K9/127;A61K47/48;C07F9/10;C07H21/04;C07K14/00;C07K14/195;C07K14/435;C07K14/47;C12N15/64;(IPC1-7):C12N15/87 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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