发明名称 |
Compositions and methods for modifying a predetermined target nucleic acid sequence |
摘要 |
Disclosed herein are compositions and methods, similar to CRISPR/Cas9 systems, for modifying a predetermined nucleic acid sequence. A programmable nucleoprotein molecular complex which assembles in-vivo in a target cell comprising a) a polypeptide moiety which comprises a functional domain and a linking domain, and b) a specificity conferring nucleic acid (SCNA) which comprises a complementary region and a recognition region capable of attaching to the linking domain. The programmable nucleoprotein molecular complex is capable of interacting with the predetermined target nucleic acid sequence and is capable of specifically modifying and/or editing a target site within the target nucleic acid sequence and/or modifying the function of the target nucleic acid sequence. |
申请公布号 |
NZ626105(A) |
申请公布日期 |
2016.11.25 |
申请号 |
NZ20120626105 |
申请日期 |
2012.12.16 |
申请人 |
TARGETGENE BIOTECHNOLOGIES LTD |
发明人 |
SHIBOLETH YOEL MOSHE;WEINTHAL DAN MICHAEL |
分类号 |
A61K31/7105;A61K31/711;A61K31/7115;A61K31/712;A61K31/7125;A61K31/713;A61K48/00;C07K19/00;C12N5/10;C12N15/62 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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