| 发明名称 | Stabilized chitosan-based nanoparticles and methods for making the same | ||
| 摘要 | A stabilized chitosan-based nanoparticle is provided having a chitosan polymer and a hydrophilic dispersing agent. In the stabilized nanoparticle, chains of the chitosan polymer electrostatically interact with chains of the hydrophilic dispersing agent to form an entangled network between the chitosan polymer and the hydrophilic dispersing agent. The stabilized chitosan-based nanoparticle has optimal particle integrity and stability properties under physiological conditions. | ||
| 申请公布号 | US9504761(B2) | 申请公布日期 | 2016.11.29 |
| 申请号 | US201113090732 | 申请日期 | 2011.04.20 |
| 申请人 | University of Central Florida Research Foundation, Inc. | 发明人 | Santra Swadeshmukul;Turkson James;Malhotra Astha;Tallury Padmavathy |
| 分类号 | A61K47/48;C08B37/00;C08L5/08;C08L77/00;C08J3/16;C08B37/08 | 主分类号 | A61K47/48 |
| 代理机构 | Beusse, Wolter, Sanks & Maire, PLLC | 代理人 | Van Dyke Timothy H.;Beusse, Wolter, Sanks & Maire, PLLC |
| 主权项 | 1. A stabilized chitosan-based nanoparticle comprising: a chitosan polymer and a polyglutamic acid; wherein chains of the chitosan polymer electrostatically interact with chains of the the polyglutamic acid to form an entangled network comprising the chitosan polymer and the polyglutamic acid; and wherein the polyglutamic acid and the chitosan polymer are at a molar ratio of from 1:5 to 1:20 polyglutamic acid to chitosan polymer and the polyglutamic acid is of a molecular weight such that the nanoparticle has a particle size of between about 20 nm and about 100 nm and has a zeta potential of at least +32 mV. | ||
| 地址 | Orlando FL US | ||