METHOD OF OLIGONUCLEOTIDE DUPLEX STABILIZATION

摘要

FIELD: molecular biology, pharmacology. SUBSTANCE: invention proposes an interaction of oligodeoxyribonucleotide conjugates with small-groove ligands. Stabilized duplexes can be used in hybridous diagnosis to increase a sensitivity threshold of a method and in medicine as antigenous and "nonsense" preparations. EFFECT: improved method of stabilization. 2 cl, 3 dwg, 1 tbl, 12 ex