| 摘要 |
<p>PCT No. PCT/EP94/03129 Sec. 371 Date Mar. 21, 1996 Sec. 102(e) Date Mar. 21, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08549 PCT Pub. Date Mar. 30, 1995The present invention relates to piperidine derivatives of formula (I) <IMAGE> (I) wherein R1 is a C1-4alkoxy group; R2 is <IMAGE> R3 is a hydrogen or halogen atom; R4 and R5 may each independently represent a hydrogen or halogen atom, or a C1-4alkyl, C1-4alkoxy or trifluoromethyl group; R6 is a hydrogen atom, a C1-4alkyl, (CH2)mcyclopropyl, -S(O)nC1-4alkyl, phenyl, NR7R8, CH2C(O)CF3 or trifluoromethyl group; R7 and R8 may each independently represent a hydrogen atom, or a C1-4alkyl or acyl group; x represents zero or 1; n represents zero, 1 or 2; m represents zero or 1; and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation; and their use in the treatment of conditions mediated by tachykinins.</p> |
