| 摘要 |
<p>The optically pure R-isomer of the adrenergic beta-agonists albuterol, terbutaline and salmeterol, substantially free of their corresponding S-isomer, and the optically pure RR-isomer of the beta-agonist fenoterol and formoterol, substantially free of their corresponding SS-isomer, have been found to be rapidly and safely absorbed by transdermal administration, rectal administration, sublingual and enteric coated drug administration, and by nasal insufflation, while avoiding the racemization of the compounds that surprisingly has been shown to take place in the acid environment in the stomach. New methods are disclosed utilizing transdermal, rectal, sublingual and enteric coated administration and nasal insufflation of the optically pure eutomer of these adrenergic beta-2 agonists for treating various diseases, while avoiding the side effects for the distomer of said drugs, said side effects being known to those skilled in the art and include but are not restricted to bronchial hyperreactivity, fetal bronchial hyperreactivity, increases of intraocular pressure, uterine smooth muscle hyperreactivity, teratogenic and other forms of toxicity. Transdermal, rectal, sublingual and enteric coated administration or nasal insufflation of an eutomer of said adrenergic beta-agonists also avoids chemical and metabolic degradation in the upper gastrointestinal tract while minimizing the side effects associated with the administration of the corresponding distomers.</p> |
