| 发明名称 |
RNAi inhibition of alpha-ENaC expression |
| 摘要 |
The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides. |
| 申请公布号 |
US9476052(B2) |
申请公布日期 |
2016.10.25 |
| 申请号 |
US201514729104 |
申请日期 |
2015.06.03 |
| 申请人 |
Arrowhead Pharmaceuticals, Inc. |
发明人 |
Van Heeke Gino;Hickman Emma;Danahay Henry Luke;Tan Pamela;Geick Anke;Vornlocher Hans-Peter |
| 分类号 |
C12N15/11;C12N15/113 |
主分类号 |
C12N15/11 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising an iRNA agent comprising a sense strand and an antisense strand, wherein:
a. the antisense strand comprises the nucleotide sequence of nucleotides 1-19 of SEQ ID NO: 980. |
| 地址 |
Pasadena CA US |
